Table 1.
Demographic and medical history across subjects
| All Subjects | Normal | Other Parasomnia | RSWA | RBD | |||
|---|---|---|---|---|---|---|---|
| n = 394 | n = 211 (53%) | n = 122 (31%) | n = 27 (7%) | n = 34 (9%) | Stat. | P | |
| Demographics | |||||||
| Age (years) | 54.4 ± 15.5 | 58.6 ± 14.4 | 48.5 ± 15.9* | 54.1 ± 14.4 | 49.6 ± 13.8* | 13.12 | <0.0001 |
| BMI (kg/m2) | 32.7 ± 6.8 | 32.8 ± 6.5 | 32.4 ± 7.5 | 33.4 ± 5.9 | 32.5 ± 6.6 | 0.21 | 0.887 |
| Sex (male) | 369 (94%) | 196 (93%) | 115 (94%) | 25 (93%) | 32 (94%) | 0.17 | 0.982 |
| TBI and/or PTSD | 150 (38%) | 50 (24%) | 69 (57%)* | 10 (37%) | 21 (62%)* | 16.46 | <0.0001 |
| Medical History | |||||||
| OSA | 327 (83%) | 178 (84%) | 95 (78%) | 26 (96%) | 28 (82%) | 5.95 | 0.114 |
| Cognitive Impairment | 6 (2%) | 4 (2%) | 2 (2%) | 0 (0%) | 0 (0%) | - | 1.0 |
| Lung disease | 53 (13%) | 29 (14%) | 20 (16%) | 2 (7%) | 2 (6%) | 3.44 | 0.328 |
| Heart disease | 81 (20%) | 51 (23%) | 18 (15%) | 4 (14%) | 8 (23%) | 4.93 | 0.177 |
| Stroke | 10 (3%) | 8 (4%) | 1 (1%) | 0 | 1 (3%) | 3.52 | 0.345 |
| Hypertension | 178 (45%) | 102 (48%) | 50 (41%) | 9 (32%) | 15 (44%) | 3.85 | 0.284 |
| Diabetes | 88 (22%) | 51 (24%) | 22 (18%) | 7 (25%) | 8 (24%) | 1.94 | 0.585 |
| Parkinson’s Disease | 2 (1%) | 1 (1%) | 1 (1%) | 0 | 0 | - | 1.0 |
| Sleep Drug Use | |||||||
| Melatonin | 17 (4%) | 7 (3%) | 5 (4%) | 1 (4%) | 4 (11%) | 5.11 | 0.163 |
| Clonazepam | 5 (2%) | 2 (1%) | 3 (1%) | 0 | 0 | - | 1.0 |
Data are mean ± standard deviation, or n (% of total).
BMI = body mass index; OSA = obstructive sleep apnea; Cognitive Impairment (history of Alzheimer’s, dementia, or mild cognitive impairment); RSWA = REM sleep without atonia; RBD = REM sleep behavior disorder; Stat = F or chi-square statistic.
*p < 0.05 vs Normal. One-way ANOVA with Tukey HSD post hoc analysis; chi-square with Bonferroni post hoc test or Fisher’s exact test for categorical variables with n’s < 5.
Alpha for these omnibus comparisons has been corrected (i.e. 0.05/14 = 0.003). p values for all significant post hoc multiple comparisons are <0.0006.