Figure 1.

Effects of 10 h of automated sleep disruption on sleep physiology. (A) Hypnograms between ZT0 and ZT10 for 5 mice during baseline undisrupted sleep (top) and during 10 h of sleep disruption (mSD) (bottom). (B) Mice undergoing 10 h of sleep disruption show significant decreases in total sleep time, NREM duration, and REM duration, and significant increases in percent wake time and number of state transitions. (C) Survival curves (cumulative probability distributions) of wake, NREM, and REM runs in the normal baseline sleep and sleep disrupted conditions demonstrate significant fragmentation of all vigilance states. ** p < 0.01.