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. 2019 Oct 14;43(3):zsz244. doi: 10.1093/sleep/zsz244

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Figure 6. — Inhibition of S6 kinase signaling with PF-4708671 prior to motor learning impairs offline gains in motor performance. (A) Trial-by-trial rotarod performance on day 1 and day 2 for mice treated with PF-4708671 (PF, n = 8) or vehicle control (vehicle, n = 12). (B) Mice treated with vehicle demonstrate significant improvement in the first 3 trials of day 2 (F3D2) compared to the last 3 trials of day 1 (L3D1) whereas mice treated with PF-4708671 do not. There was no significant difference in L3D1 performance between treatments. (C) Offline improvement in motor performance expressed as F3D2/L3D1 was significantly higher in mice treated with vehicle vs. PF-4708671. ** p < 0.01. n.s. = not significant.