Table 5.
Small Molecules Targeting Host Factors and Unknown Targets
| Name | Chemical structure | IC50 | Targets | Ref |
|---|---|---|---|---|
| Chlorpromazine (25) |
|
7.24 μM | clathrin-mediated endocytosis | 122 |
| fluphenazine (26) |
|
3.23 μM | clathrin-mediated endocytosis | 122 |
| promethazine (27) |
|
7.48 μM | clathrin-mediated endocytosis | 122 |
| imatinib (28) |
|
10 μM | Abl2 | 123, 124 |
| dasatinib (29) |
|
2.1-5.4 μM | Abl | 125 |
| saracatinib (30) |
|
2.4-5.1 μM | SFK signaling pathways | 126 |
| emodin (31) |
|
200 μM | - | 131 |
| SSAA09E3 (32) |
|
9.7 μM | - | 57 |
| VE607 (33) |
|
1.6 μM | - | 132 |