Table 3:
HemeChip diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) in comparison to reference standard method.
| SCD-SS vs. others | SCD-SC vs. others | SCD Trait vs. others | Hb E Disease vs. others | Hb E Trait vs. others | |
|---|---|---|---|---|---|
| True positive, TP | 33 | 14 | 129 | 15 | 57 |
| True negative, TN | 687 | 706 | 591 | 705 | 663 |
| False Positive, FP | 9 | 0 | 0 | 0 | 0 |
| False negative, FN | 0 | 0 | 0 | 0 | 0 |
| Sensitivity, TP/(TP + FN) | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% |
| Specificity, TN/(TN + FP) | 98.7% | 100.0% | 100.0% | 100.0% | 100.0% |
| PPV, TP/(TP + FP) | 78.6% | 100.0% | 100.0% | 100.0% | 100.0% |
| NPV, TN/(TN + FN) | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% |
HemeChip reports hemoglobin C/E/A2. Test location was used to differentiate co-migrating hemoglobins C and E.