Table 2.
Frequencies of inhibitory and activatory KIRs in RPL and healthy control couples
| Variable | Female RPL (n = 25) | Female healthy contro l (n = 39) | Male RPL (n = 25) | Male healthy control (n = 44) | p-value |
|---|---|---|---|---|---|
| Inhibitory KIR | |||||
| 2DL2 | 52 | 41 | 56 | 43.2 | NS |
| 2DL3 | 92 | 84.6 | 92 | 93.2 | NS |
| 2DL5a) | 70.4b,c) | 43.6b) | 72b,c) | 31.8c) | 0.03b), 0.001c) |
| Activatory KIR | |||||
| 2DS1 | 52 | 35.9 | 56 | 52.3 | NS |
| 2DS2 | 52 | 51.3 | 56 | 52.3 | NS |
| 2DS3d) | 20 | 28.2b) | 4b,c) | 40.9c) | 0.02b), 0.001c) |
| 2DS4 | 100 | 89.7 | 100 | 90.9 | NS |
| 2DS5 | 36 | 25.6 | 32 | 40.9 | NS |
| 3DS1 | 40 | 25.6 | 32 | 54.5 | NS |
Values are presented as percent.
KIR, killer-cell immunoglobulin-like receptor; RPL, recurrent pregnancy loss; NS, not significant.
a)
Odds ratio for KIR2DL5: 3.07 and 5.5 for the comparison between women and men, respectively;
b)
Comparison to female;
c)
Comparison to male;
d)
Odds ratio for KIR2DS3: 0.17 compared to female partners of RPL couples and 0.06 compared to heathy control men.