Table 1.
Genetic correlations analysis results between psychiatric disorders and blood plasma protein (p value <0.05)
| Psychiatric disorders | Blood plasma protein | Coefficients | p values |
|---|---|---|---|
| ADHD | Lysosomal Pro-X carboxypeptidase | 0.243 | 0.015 |
| Alpha-2-antiplasmin | 0.274 | 0.032 | |
| ASD | Extracellular superoxide dismutase (Cu-Zn) | 0.530 | 0.023 |
| Hepatitis A virus cellular receptor 1 | 0.405 | 0.031 | |
| Chromogranin-A | 0.409 | 0.034 | |
| Pro-opiomelanocortin | 0.523 | 0.041 | |
| Cysteine-rich hydrophobic domain-containing protein 2 | 0.263 | 0.043 | |
| Trypsin-1 | 0.370 | 0.047 | |
| BD | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 | 0.419 | 0.007 |
| Tumor necrosis factor receptor superfamily member 1B | −0.383 | 0.012 | |
| Guanine nucleotide exchange factor VAV3 | −0.270 | 0.018 | |
| Insulin-like growth factor-binding protein 6 | −0.377 | 0.022 | |
| Rho guanine nucleotide exchange factor 10 | −0.304 | 0.022 | |
| Sodium-coupled monocarboxylate transporter 1.sumstats | −0.210 | 0.027 | |
| Normal mucosa of esophagus-specific gene 1 protein | −0.215 | 0.030 | |
| Muscle, skeletal receptor tyrosine-protein kinase | −0.200 | 0.033 | |
| MDD | Trefoil factor 1 | −0.287 | 0.011 |
| Bone morphogenetic protein 7 | 0.392 | 0.012 | |
| Peregrin | 0.361 | 0.013 | |
| Beta-defensin 118 | 0.328 | 0.014 | |
| Neurensin-1 | −0.359 | 0.026 | |
| Multimerin-2 | 0.322 | 0.026 | |
| Matrix metalloproteinase-17 | 0.358 | 0.026 | |
| Intercellular adhesion molecule 3 | 0.241 | 0.036 | |
| Tumor necrosis factor receptor superfamily member 8 | 0.297 | 0.040 | |
| Neurotensin/neuromedin N | 0.313 | 0.041 | |
| Cyclin-dependent kinase 2:Cyclin-A2 complex | 0.443 | 0.045 | |
| Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | −0.336 | 0.048 | |
| Trefoil factor 1 | −0.287 | 0.011 | |
| SCZ | Insulin-like growth factor-binding protein 6 | −0.396 | 0.011 |
| Cathepsin Z | −0.349 | 0.012 | |
| Sphingosine kinase 2 | 0.212 | 0.018 | |
| Tropomyosin alpha-1 chain | 0.264 | 0.021 | |
| CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 0.269 | 0.028 | |
| Protein NOV homolog | 0.196 | 0.028 | |
| Normal mucosa of esophagus-specific gene 1 protein | −0.167 | 0.030 | |
| Alpha-L-iduronidase | −0.260 | 0.032 | |
| Potassium voltage-gated channel subfamily E member 2 | 0.182 | 0.039 | |
| Cell surface glycoprotein CD200 receptor 2 | −0.233 | 0.041 | |
| Profilin-2 | −0.329 | 0.042 | |
| Ubiquitin-conjugating enzyme E2 T | 0.264 | 0.043 | |
| Rho guanine nucleotide exchange factor 10 | −0.229 | 0.044 | |
| Tumor necrosis factor receptor superfamily member 1B | −0.292 | 0.045 | |
| Disintegrin and metalloproteinase domain-containing protein 29 | 0.272 | 0.048 |
Abbreviations: ADHD, attention deficiency/hyperactive disorder; ASD, autism spectrum disorder; BD, bipolar disorder; MDD, major depressive disorder; SCZ, schizophrenia.