Table 1.
DDR Inhibitors in Past or Present Clinical Evaluation
| PARP Inhibitors | CHK1 Inhibitor | ATR Inhibitors |
|---|---|---|
| Niraparib (MK-4827)1 | GDC-0575 | Ceralasertib (AZD6738) |
| Olaparib (AZD-2281)1 | LY3300054 | BAY1895344 |
| Talazoparib (BMN-673) 1 | MK-8776 (SCH-900776) | Berzosertib (M6620, VX-970) |
| Rucaparib (AG-014699)1 | Prexasertib (LY2606368) | M4344 (VX-803) |
| Pamiparib (BGB-290) | SRA-737 (CCT245737) | |
| Veliparib (ABT-888) | AZD77622 | |
| CEP-97222 | ||
| E7016 (GPI-21016)2 | ||
| INO-10012 | ||
| DNA-PK Inhibitors | WEE1 Inhibitors | ATM Inhibitors |
| AZD7648 | Adavosertib (AZD1775) | AZD0156 |
| CC-115 | M3541 | |
| M9831 (VX-984) | ||
| Nedisertib (M3814) |
1
FDA approved
2
No longer in clinical trials