Table 1:
Patient Demographics, Disease and Treatment Characteristics by Radiation Pneumonitis Grades
| All patients | Grade 2 RP (%) | Grade 3–5 RP (%) | p value | Non-lethal RP (%) | Lethal RP (%) | p-value | |
|---|---|---|---|---|---|---|---|
| Age (year) | 0.25 | 0.03 | |||||
| Median | 67.5 | 65 | 73 | 66 | 76 | ||
| Range | 38–83 | 46–83 | 38–82 | 38–83 | 60–82 | ||
| Gender | 1.00 | 0.69 | |||||
| Female | 47 | 34 (72%) | 13 (28%) | 42 (89%) | 5 (11%) | ||
| Male | 35 | 26 (74%) | 9 (26%) | 33 (94%) | 2 (6%) | ||
| Race | 1.00 | 0.24 | |||||
| White | 79 | 58 (73%) | 21 (27%) | 73 (92%) | 6 (8%) | ||
| African American | 3 | 2 (67%) | 1 (33%) | 2 (67%) | 1 (33%) | ||
| Performance Status | 0.04 | 0.43 | |||||
| 0/1 | 76 | 58 (76%) | 18 (24%) | 70 (92%) | 6 (8%) | ||
| 2/3 | 6 | 2 (33%) | 4 (67%) | 5 (83%) | 1 (17%) | ||
| Smoking Status | 0.70 | 1.00 | |||||
| Never Smoker | 9 | 6 (67%) | 3 (33%) | 9 (100%) | 0 | ||
| Former/Current Smoker | 73 | 54 (74%) | 19 (26%) | 66 (90%) | 7 (10%) | ||
| Pack-Years | 0.26 | 0.22 | |||||
| Median | 40 | 50 | 53.5 | 40 | 57 | ||
| Histology | 0.03 | 0.03 | |||||
| Squamous Cell Carcinoma | 25 | 14 (56%) | 11 (44%) | 20 (80%) | 5 (20%) | ||
| Other | 57 | 46 (81%) | 11 (19%) | 55 (97%) | 2 (3%) | ||
| Clinical Stage | 0.80 | 0.69 | |||||
| I/II | 29 | 22 (75.9%) | 7 (24.1%) | 26 (89.7%) | 3 (10.3%) | ||
| III/IV | 53 | 38 (71.7%) | 15 (28.3%) | 49 (92.5%) | 4 (7.5%) | ||
| FEV1 | 0.009 | 0.24 | |||||
| ≤2 | 32 | 17 (53%) | 15 (47%) | 27 (84%) | 5 (16%) | ||
| >2 | 36 | 30 (83%) | 6 (17%) | 34 (94%) | 2 (6%) | ||
| Missing | 14 | 13 | 1 | 14 | 0 | ||
| Predicted FEV1 (%) | 0.30 | 0.43 | |||||
| ≤80 | 35 | 22 (63%) | 13 (37%) | 30 (86%) | 5 (14%) | ||
| >80 | 33 | 25 (76%) | 8 (24%) | 31 (94%) | 2 (6%) | ||
| Missing | 14 | 13 | 1 | 14 | 0 | ||
| History of COPD | 0.12 | 0.20 | |||||
| No | 56 | 44 (79%) | 12 (21%) | 53 (95%) | 3 (5%) | ||
| Yes | 26 | 16 (62%) | 10 (38%) | 22 (85%) | 4 (15%) | ||
| History of Fibrosis | 0.07 | 0.16 | |||||
| No | 80 | 60 (75%) | 20 (25%) | 74 (93%) | 6 (7%) | ||
| Yes | 2 | 0 | 2 (100%) | 1 (50%) | 1 (50%) | ||
| RT Technique | 1.00 | 0.67 | |||||
| 3DCRT | 60 | 44 (73%) | 16 (27%) | 54 (90%) | 6 (10%) | ||
| IMRT or 3DCRT+IMRT | 22 | 16 (73%) | 6 (27%) | 21 (96%) | 1 (4%) | ||
| Gross Tumor Volume | 0.22 | 0.70 | |||||
| Primary Tumor, Hilar and Mediastinal Nodes | 39 | 26 (67%) | 13 (33%) | 35 (90%) | 4 (10%) | ||
| Other | 43 | 34 (79%) | 9 (21%) | 40 (93%) | 3 (7%) | ||
| RT Dose | 1.00 | 0.69 | |||||
| <66 Gy | 48 | 35 (73%) | 13 (27%) | 43 (90%) | 5 (10%) | ||
| ≥66 Gy | 34 | 25 (75%) | 9 (25%) | 32 (94%) | 2 (6%) | ||
| Mean Lung Dose# | 0.79 | 1.00 | |||||
| ≤17 | 44 | 33 (76%) | 11 (25%) | 40 (91%) | 4 (9%) | ||
| >17 | 30 | 21 (70%) | 9 (30%) | 28 (93%) | 2 (7%) | ||
| Missing | 8 | 6 | 2 | 7 | 1 | ||
| Lung V20† | 0.79 | 1.00 | |||||
| ≤30 | 47 | 35 (75%) | 12 (24%) | 43 (92%) | 4 (8%) | ||
| >30 | 27 | 19 (70%) | 8 (30%) | 25 (93%) | 2 (7%) | ||
| Missing | 8 | 6 | 2 | 7 | 1 |
*
p-value based on Fisher’s exact for categorical variables and Wilcoxon rank sum test for continuous variables
#
Mean Lung Dose of patients with lethal RP had a median of 15.0 Gy (range: 6.2 – 18.2).
†
Lung V20 of patients with lethal RP had a median of 25.75% (range: 9.0 – 33.8)
RP – radiation pneumonitis, FEV1 – forced expiratory volume 1, COPD – chronic obstructive pulmonary disease, RT – radiation therapy, 3DCRT – three-dimensional conformal radiation therapy, IMRT – intensity modulated radiation therapy, lung V20 – volume of normal lung receiving 20 Gy