Table 2:
Patient Demographics, Disease and Treatment Characteristics by Radiation Pneumonitis Grades
| All Patients | Grade 2 RP (%) | Grade 3–5 RP (%) | p-value | Non-lethal RP (%) | Lethal RP (%) | p-value | |
|---|---|---|---|---|---|---|---|
| Extent* | 0.003 | 0.0008 | |||||
| Median | 8.5 | 8 | 12 | 8 | 15 | ||
| Range | 3–15 | 3–12 | 4–15 | 3–15 | 8–15 | ||
| Distribution | <0.0001 | 0.0003 | |||||
| Diffuse | 11 | 2 (18%) | 9 (82%) | 6 (55%) | 5 (45%) | ||
| Other | 71 | 58 (82%) | 13 (18%) | 69 (97%) | 2 (3%) | ||
| Bilateral Involvement | 0.14 | 0.23 | |||||
| Yes | 48 | 32 (67%) | 16 (33%) | 42 (88%) | 6 (12%) | ||
| No | 34 | 28 (82%) | 6 (18%) | 33 (97%) | 1 (3%) | ||
| All Lobe Involvement | 0.11 | 0.006 | |||||
| Yes | 28 | 17 (61%) | 11 (39%) | 22 (79%) | 6 (21%) | ||
| No | 54 | 43 (80%) | 11 (20%) | 53 (98%) | 1 (2%) | ||
| Out of Field | 0.75 | 0.34 | |||||
| Yes | 67 | 48 (72%) | 19 (28%) | 60 (90%) | 7 (10%) | ||
| No | 15 | 12 (80%) | 3 (20%) | 15 (100%) | 0 | ||
| Radiographic Pattern | 0.0003 | 0.0002 | |||||
| AIP/ARDS patterns | 10 | 2 (20.0%) | 8 (80.0%) | 5 (50.0%) | 5 (50.0%) | ||
| Other patterns | 72 | 58 (80.6%) | 14 (19.4%) | 70 (97.2%) | 2 (2.8%) |
RP – radiation pneumonitis, AIP/ARDS – acute interstitial pneumonia/acute respiratory distress syndrome
*
Extent was obtained for each patient as the sum of the scores in the upper, and middle, and lower lungs.