Table 3:
Logistic Regression for the association between Radiation Pneumonitis Grades and Clinical Characteristics
| Grade 3–5 RP vs. Grade 2 RP | Lethal RP vs. Non-Lethal RP | |||
|---|---|---|---|---|
| OR3 (95% CI) | p-value | OR3 95% CI) | p-value | |
| Age at RT Start (year) | 0.0504 | 0.08 | ||
| ≤67 | Ref. | Ref. | ||
| >67 | 2.80 (0.998, 7.98) | 6.86 (0.79, 59.8) | ||
| Gender | 0.84 | 0.44 | ||
| Female | Ref. | Ref. | ||
| Male | 0.91 (0.34, 2.44) | 0.51 (0.09, 2.79) | ||
| Race | 0.80 | 0.16 | ||
| White | 0.72 (0.06, 8.41) | 0.16 (0.01, 2.09) | ||
| African American | Ref. | Ref. | ||
| Performance Status | 0.04 | |||
| 0/1 | Ref. | Ref. | ||
| 2/3 | 6.44 (1.09, 38.13) | 2.33 (0.23, 23.4) | ||
| Smoking Status | 0.64 | |||
| Never Smoker | Ref. | - | - | |
| Former/Current Smoker | 0.70 (0.16, 3.10) | - | - | |
| Histology | 0.02 | 0.03 | ||
| Squamous Cell Carcinoma | 3.29 (1.18, 9.18) | 6.88 (1.23, 38.31) | ||
| Other | Ref. | Ref. | ||
| Clinical Stage | 0.68 | 0.67 | ||
| I/II | Ref. | Ref. | ||
| III/IV | 1.24 (0.44, 3.51) | 0.71 (0.15, 3.40) | ||
| FEV1 | 0.008 | 0.42 | ||
| ≤2 | 4.41 (1.44, 13.50) | 3.15 (0.57, 17.51) | ||
| >2 | Ref. | Ref. | ||
| Missing1 | 0.39 (0.04, 3.52) | - | ||
| Predicated FEV1 (%) | 0.13 | 0.55 | ||
| ≤80 | Ref. | Ref. | ||
| >80 | 0.54 (0.19, 1.55) | 0.39 (0.07, 2.15) | ||
| Missing1 | 0.13 (0.02, 1.11) | - | ||
| History of COPD | 0.11 | 0.15 | ||
| No | Ref. | Ref. | ||
| Yes | 2.29 (0.83, 6.33) | 3.21 (0.66, 15.55) | ||
| RT Technique | 0.96 | |||
| 3DCRT | 0.97 (0.32, 2.91) | 2.33 (0.27, 20.56) | ||
| IMRT or 3DCRT+IMRT | Ref. | Ref. | ||
| GTV | 0.21 | 0.60 | ||
| Primary Tumor, Hilar and Mediastinal Nodes | 1.89 (0.70, 5.09) | 1.52 (0.32, 7.28) | ||
| Other/Missing | Ref. | Ref. | ||
| RT Dose | 0.95 | 0.47 | ||
| <66 Gy | Ref. | Ref. | ||
| ≥66 Gy | 0.97 (0.36, 2.62) | 0.54 (0.10, 2.95) | ||
| Mean Lung Dose | 0.63 | 0.71 | ||
| ≤17 | Ref. | Ref. | ||
| >17 | 1.29 (0.46, 3.63) | 0.71 (0.12, 4.17) | ||
| Lung V20 | 0.70 | 0.87 | ||
| ≤30 | Ref. | Ref. | ||
| >30 | 1.23 (0.43, 3.53) | 0.86 (0.15, 5.04) | ||
RP – radiation pneumonitis, RT – radiation therapy, OR – odds ratio, CI – confidence interval, FEV1 – forced expiratory volume 1, COPD – chronic obstructive pulmonary disease, 3DCRT – three-dimensional conformal radiation therapy, IMRT – intensity modulated radiation therapy, GTV – gross tumor volume, lung V20 – volume of normal lung receiving 20 Gy
1.
Missing category with greater than 10 patients was included in the model.
2.
Odds ratio
3.
Variables with p<0.05 in the univariable analysis were included in the multivariable analysis.