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. Author manuscript; available in PMC: 2020 Jun 25.
Published in final edited form as: Annu Rev Biochem. 2020 Jun 20;89:45–75. doi: 10.1146/annurev-biochem-013118-111843

Figure 8.

Figure 8.

Mechanism of −S• mediated NDP reduction by most RNRs (5). Steps A–F are the proposed steps in the reaction and 16 represent the active site participants in each step. Note that steps A, C, D, and E involve either hydrogen atom transfer (HAT) or proton coupled electron transfer (PCET) processes.