Skip to main content
. Author manuscript; available in PMC: 2020 Jun 25.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2018 Sep 24;1865(8):2060–2067. doi: 10.1016/j.bbadis.2018.09.025

Fig. 3.

Fig. 3.

Cytosolic acetyl-CoA metabolism and protein acetylation. Citrate generated from acetyl-CoA is transported into the cytosol where it is a substrate for ATP citrate lyase (ACLY). This enzyme converts citrate back to acetyl-CoA in the presence of ATP. Acetyl-CoA can be also synthetized by cytosolic acetyl-CoA synthetase (ACECS1) from acetate, CoA and ATP. Similarly, as in mitochondria, acetyl-CoA is used for acetylation of proteins by acetyltransferases (KAT). The acetylated proteins are deacetylated by sirtuins where the deacetylation is coupled to NAD+ hydrolysis and o-acetyl-ADP-ribose is released.