Fig 8. Effect of Debye Length on reactivity of the sequential enzymes.

a)Reaction rate of CD39, k_on,ATP, as a function of Debye length parameter (κ) which is proportional to the square root of ionic strength. The circle shows simulation data and the solid lines are obtained by fitting to Eq 4. The subplot shows the linear relationship between ln(k_on) and (1 + aκ)⁻¹. Linear regression of Eq 4 yields the interaction strength U/RT and ln k_{on,I → ∞} (see Table 1). b)Production and effective reaction rates versus κ. The solid lines correspond to the left axis (k_prod,Ado) and the dashed to the right axis (k_eff).