Table 1. Peripheral immune activation and CNS immune cell infiltration.

Immune activation	N (WT EAE, Sarm1 KO EAE)	Effect size: Sarm1 KO EAE vs. WT EAE [95% confidence interval]	Mann Whitney p
IL-4 (pg/ml)	7, 10	3.03 [-4.74, 14.7]	0.92
IL-17 (pg/ml)	7, 10	440 [–259, 1410]	0.96
IFN-γ (pg/ml)	7, 10	5.31x103 [-2.25x103, 1.22x104]	0.30
CD25+Foxp3+ (%CD3+CD4+)	6, 7	-1.14 [-5.86, 3.96]	0.45
CD4+Ki67+ (%CD3+)	6, 7	-0.751 [-2.34, 1.17]	0.29
CNS inflammatory cells (absolute counts)	N (WT EAE, Sarm1 KO EAE)	Effect size: Sarm1 KO EAE vs. WT EAE [95% confidence interval]	Mann Whitney p
total leukocytes	6, 7	-1.96x105 [-5.26x105, 1.58x105]	0.29
Microglia	6, 7	-2.42x104 [-7.95x104, 2.47x104]	0.53
Macrophage	6, 7	-1.13x105 [-3.24x105, 9.51x104]	0.37
CD11b+Ly6Chi	6, 7	-1.03x105 [-2.39x105, 6x104]	0.37
CD11b+CD11c+	6, 7	-2.66x104 [-9.88x104, 3.99x104]	0.73
T cells (CD3+)	6, 7	-3.07x104 [-8.96x104, 5.05x104]	0.29
CD3+CD4+ T cells	6, 7	-8.15x103 [-5.9x104, 4.73x104]	0.95
CD3+CD8+ T cells	6, 7	-2.09x104 [-6.62x104, 4.71x102]	0.37
B cells	6, 7	2.31x103 [-2.61x103, 9.32x103]	0.73
Neutrophils	6, 7	-1.45x104 [-4.76x104, 6.11x103]	0.73