Table 2.
Adult progenitor cells and progeny at homeostasis and after injury.
| Location | Progenitor cell type | Context | Progeny cell type |
|---|---|---|---|
| Submucosal glands of airway | Myoepithelial cell | Naphthalene, sulfur dioxide, influenza injury | Myoepithelial, transitional basal cell to secretory and multiciliated cells |
| Conducting airway | Basal Cells | Homeostasis | Basal, secretory, tuft, neuroendocrine, and ionocytes |
| Sulfur dioxide, naphthalene | Basal, secretory, multiciliated cells | ||
| Influenza | SOX2+/KRT5+/TRP63+ basal transition cell into AT2s upon inhibition of NOTCH, prevention of hypoxia-induced events, and WNT activation | ||
| Secretory Cells | Homeostasis | Secretory, multiciliated cells | |
| Basal cell depletion, sulfur dioxide, influenza | Dedifferentiated basal, secretory, multiciliated cells | ||
| Naphthalene, sulfur dioxide | Basal, secretory, tuft, neuroendocrine, and ionocytes | ||
| Variant Secretory (NEB niche) | Homeostasis or naphthalene injury | Secretory, multiciliated cells | |
| Bleomycin | AT2s, AT1s | ||
| Bronchioalveolar stem cells | Homeostasis | Secretory and AT2, (rare AT1) | |
| Naphthalene | Secretory, multiciliated cells | ||
| Bleomycin | AT2, AT1 | ||
| Influenza | Secretory, AT2 | ||
| Alveolar | Type 1 | Homeostasis, | AT1 |
| Pneumonectomy | AT1, AT2 | ||
| Type 2 | Homeostasis, bleomycin, AT2 depletion model, pneumonectomy | AT2, AT1 | |
| AEP | Homeostasis | AT2 (rare AT1) | |
| Influenza, lung epithelial deletion model | AT2, AT1 | ||
| a4b6/SFTPC- | Bleomycin | AT2s |