. Author manuscript; available in PMC: 2020 Jun 25.

Published in final edited form as: Int J Toxicol. 2010 May-Jun;29(3):291–296. doi: 10.1177/1091581810362804

Table 4.

Pooled Proliferative Lesions in Male or Female Tg.AC Mice Exposed to Either Level of Arsenic Regardless of Other Treatment and Compared With Control^a

		Bladder, n (%)		Uterus, n (%)
Pooled Treatment Group	Adrenal Adenoma, n (%)	Hyperplasia	Papilloma	Hyperplasia	Tumors
Control	0/49 (0)	0/49 (0)	0/49 (0)	1/25 (4)	0/25 (0)
TPA alone	0/47 (0)	2/47 (4)	0/47 (0)	1/24 (4)	0/24 (0)
All As^b	46/192 (24)^c	52/192 (27)^c	2/192 (1)	33/95 (35)^c	3/95 (3)
As alone	22/95 (23)^c	16/95 (17)^c	1/95 (1)	17/47(36)^c	3/47 (6)
As + TPA	24/97 (25)^c	20/97 (21)^c	1/97 (1)	16/48 (33)^c	0/48 (0)

As, arsenic; TPA, 12-O-tetradecanoyl phorbol-13-acetate.

See Table 2 for details.

Included animals receiving TPA as well as arsenic.

Significant difference (P < .05) from control.