Table 2.

IPA functional category analysis of genes whose expression response to arsenic at 1 year was significant for the continuous treatment regimen. Only the top 12 categories are shown for each division, in order of significance.

	No. ofgenes
Molecular and cellular functions
Cellular compromise	347
Gene expression	769
Cellular growth and proliferation	976
Cell death	951
Post-translational modification	481
Protein synthesis	366
Protein degradation	144
Molecular transport	354
Protein trafficking	135
Cell cycle	448
RNA post-transcriptional modification	123
Cell morphology	438
Top canonical pathways
Protein ubiquitination pathway	96
NRF2-mediated oxidative stress response	88
PI3/AIKT signaling	66
Molecular mechanisms of cancer	142
Purine metabolism	127
PTEN signaling	53
Integrin signaling	86
Mitochondrial dysfunction	60
Chronic myeloid leukemia signaling	50
Germ cell-sertoli cell junction signaling	67
Insulin receptor signaling	62
B cell receptor signaling	67
Top Tox lists
Oxidative stress response mediated by NRF2	89
Mitochondrial dysfunction	58
Hypoxia-inducible factor signaling	40
PPARa/RXR activation	73
Mechanism ofgene regulation by peroxisome proliferaters via PPARa	48
Hepatic cholestasis	58
NFkB signaling	51
RAR activation	58
PXR/RXR activation	29
P53 signaling	36
Aryl hydrocarbon receptor signaling	54
FXR/RXR activation	34