Table 1.
Yeast (Hsc82, Hsp82) and human (Hsp90α, Hsp90β) phosphorylation sites and identified kinases
| Residues | |||||
|---|---|---|---|---|---|
| yHsp90 | yHsc90 | hHsp90α | hHsp90β | Protein kinase | Reference |
| N/A | N/A | T5* | N/A | Ds-DNA activated protein kinase | 36 |
| N/A | N/A | T7* | N/A | Ds-DNA activated protein kinase | 36 |
| Y24* | Y24 | Y38* | Y33 | Swe1/Wee1 | 25 |
| Y47 | Y47 | Y61 | Y56* | Unknown | 57, 58 |
| S49 | N/A | S63* | S58 | Casein kinase II | 38 |
| S51 | S51 | T65* | T60 | Casein kinase II | 38 |
| N/A | N/A | S68* | S63 | Casein kinase II | 38 |
| T58 | T58 | S72* | S67 | Casein kinase II | 38 |
| N/A | N/A | T88* | T83 | Unknown | 42 |
| N/A | N/A | T90* | T85 | PKA | 59 |
| Y184 | Y184 | Y197 | Y192* | Unknown | 58 |
| N/A | N/A | S231* | S226* | Casein kinase II | 35, 37, 39 |
| N/A | N/A | S252* | N/A | Unknown | 60 |
| N/A | N/A | S263* | S255* | Casein kinase II, B-Raf | 35, 37, 39, 40 |
| S282* | S278 | N/A | N/A | Unknown | SGD |
| T285 | T281 | T305 | T297* | Unknown | 61 |
| S297* | S293 | N/A | N/A | Unknown | SGD |
| Y289 | Y285 | Y309 | Y300* | c-Src (does not exist in yeast) | 33 |
| S295 | S291 | S315 | S307* | Unknown | 62 |
| S334* | S330 | N/A | N/A | Unknown | SGD |
| S379* | S375 | S399 | S391 | Unknown | SGD |
| T443* | T429 | N/A | N/A | Unknown | SGD |
| N/A | N/A | S460 | S452* | PKA | 63 |
| Y472 | Y468 | Y492* | Y484* | Unknown | PhosphoSitePlus® |
| Y473 | Y469 | Y493* | Y485 | Unknown | PhosphoSitePlus® |
| N/A | N/A | N/A | S532* | Unknown | 62 |
| N/A | N/A | Y604* | Y596* | Unknown | PhosphoSitePlus® |
| Y606 | Y602 | Y627* | Y619* | Unknown | PhosphoSitePlus® |
| S616* | S612 | N/A | N/A | Unknown | SGD |
| S619* | S615 | N/A | N/A | Unknown | SGD |
| S657* | S653 | S677 | S668 | Unknown | 64 |
| S663* | S659 | N/A | N/A | Unknown | 64 |
| N/A | N/A | T725* | N/A | Unknown | 62 |
| N/A | N/A | S726* | S718* | Unknown | 62 |
Identified phosphorylation residues are marked by asterisk (*); orthologue residue is also shown when present. Data were taken from published literature and the websites PhosphoSitePlus® (www.phosphosite.org) and Saccharomyces Genome Database (SGD) (www.yeastgenome.org).