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. 2020 Jun 8;35(6):1421–1431. doi: 10.1093/humrep/deaa104

Figure 4.

Figure 4

Analysis of 8-h secretory patterns during vehicle and kisspeptin-10 infusion with and without NK3Ra. (A) Illustrative LH pulse profile from one subject undergoing vehicle (green diamonds), NK3Ra (purple squares), kisspeptin-10 (red triangles) and NK3Ra followed by kisspeptin-10 (blue circles) treatment visits. Mean LH pulse frequency (B), secretory mass of LH per pulse (C), basal (non-pulsatile) LH secretion (D), pulsatile LH secretion (E) and the relative orderliness/regularity of LH secretory pattern (F) during vehicle and kisspeptin-10 infusion with (n = 8) and without (n = 7) pre-treatment with NK3Ra. The NK3Ra significantly reduced LH pulse frequency. While Kp-10 alone did not affect LH pulse frequency, it did increase it in the presence of NK3Ra. Pulsatile LH secretion and LH secretory mass were increased by Kp-10, but not affected by NK3Ra. Basal LH secretion was reduced by NK3Ra, but was not stimulated by Kp-10 alone or with NK3Ra. Both NK3Ra and Kp-10 increased the relative orderliness/regularity of LH secretory pattern (i.e. reduced ApEn). Mean ± SEM. *P < 0.05.