Table II.
Summary table showing effects of KP-10 and NK3Ra (MLE4901) administration, by a consistent protocol, on gonadotropin secretion in different states of LH pulsatility and sex-steroid environments in men and women.
| Men | Postmenopausal women | Premenopausal women | Women with PCOS | |
|---|---|---|---|---|
| Study | Skorupskaite et al. (2017) | Skorupskaite et al. (2018b) | Skorupskaite et al. (2016) | Present data |
| LH status | Normal | Very high | LH surge model | High |
| Sex-steroid feedback | Negative | Loss of negative | Negative then positive | Dysregulated |
| NK3Ra response | Decreased LH | Marginal LH decrease | Marginal decrease in basal LH | Decreased LH |
| Decreased FSH | No FSH effect | Increased FSH | Decreased FSH | |
| KP-10 response | Increased LH | No LH/FSH effect | Increased LH and FSH | Increased LH |
| No FSH effect | ||||
| KP-10 and NK3Ra (vs KP-10 alone) | No change | No LH/FSH effect | Shorter KP response | Increased LH and FSH |
| Loss of relationship with oestradiol | Loss of relationship with oestradiol |