Table III.

Effects on NK3R antagonism, kisspeptin-10 infusion and their combination on various parameters of pulsatile nature of LH, and by inference GnRH secretion, in healthy men and women at different stages of reproductive life.

Group	Men	Postmenopausal women—with hot flushes	Premenopausal women—early follicular phase	Premenopausal women—LH surge model			Women with PCOS
Study	Skorupskaite et al. (2017)	Skorupskaite et al. (2018b)	Skorupskaite et al. (2018a)	Skorupskaite et al. (2016)			Present data
Treatment/Pulsatility parameter	NK3Ra	NK3Ra	NK3Ra	NK3Ra	KP-10	NK3Ra and KP-10	NK3Ra	KP-10	NK3Ra and KP-10
LH pulse frequency	No change	Decrease	No change	Decrease	Increase	Increase	Decrease	No change	Increase
LH mass per pulse	No change	Increase	No change	No change	Increase	Increase	No change	Increase	No change
Basal LH	Decrease	Decrease	Decrease	No change	Decrease	No change	Decrease	No change	No change
Pulsatile LH	Decrease	No change	No change	No change	Increase	Increase	No change	Increase	No change
ApEn (irregularity)	Decrease	No change	No change	Decrease	Decrease	Decrease	Decrease	Decrease	No change