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. Author manuscript; available in PMC: 2020 Jun 25.
Published in final edited form as: Semin Nephrol. 2019 Jan;39(1):85–95. doi: 10.1016/j.semnephrol.2018.10.008

Figure 3.

Figure 3.

The hypothesized interaction between the spleen and the kidney for the activation of dendritic cells (DCs) and T cells in angiotensin II (Ang II)-induced hypertension. Ang II with renal sympathetic nerve activity activates DCs in the kidney, leading to the migration of these cells to the spleen, where they, in turn, activate T cells. Thereafter, these activated T cells egress from the spleen and migrate to the kidney causing inflammation and hypertension. The splenic nerve is essential for T cell migration.