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. Author manuscript; available in PMC: 2020 Aug 11.
Published in final edited form as: Mucosal Immunol. 2020 Feb 11;13(4):691–701. doi: 10.1038/s41385-020-0264-z

Figure 7. Targeting IL-1 pathway during RSV infection attenuates the immunopathology response.

Figure 7.

A) Lung histopathology (H&E) showed inflammatory infiltrated and mucus (PAS staining) were reduced in lungs of mice with IL-1ra as well as B) decreased Gob 5 and Muc5 mRNA expression, and C) IL-13 and IL-5 mRNA expression. D) and E) IL-13 and IL-5 production in lung extracts. F) qPCR of total lung RNA IFNβ expression. G) Lung draining lymph nodes from mice at 8dpi were re-stimulated with RSV (MOI of 1, 48 hrs.), and T-cell cytokine levels were measured by Bio-Plex. H) ELISA of IL-33 from BAL samples collected at 6dpi. I-M) Flow cytometry of lung leukocytes, ILC2 cells, neutrophils, interstitial macrophages, dendritic cells, and T cells from naïve and infected mice at 8dpi. Data represents the Mean ± SE from 4–5 mice (experimental repeats 3–4). * P≤0.05, ** P≤.01, *** P≤0.001.