Skip to main content
. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Nat Prod Rep. 2020 May 13;37(6):797–826. doi: 10.1039/c9np00061e

Figure 3. NRF2 domain architecture and structure.

Figure 3.

A) NRF2 is comprised of seven domains termed Neh1–7 that have been defined according to biological function and homology to other protein domains. The numbering shown in the figure is for the human protein. Defined biological function of each of the domains is shown above the given domain and explained in greater detail in the text. B) The only structure of an unliganded domain of NRF2 is the NMR structure of the Neh1 domain shown (PDB ID 2LZ1). C) A crystal structure of the CNC bZip transcription factor MAFA as a potential model for the NRF2 Neh1 domain when bound to an obligate DNA-binding partner (PDB ID 4EOT). The high homology between bZip transcription factors argue this is a likely model for NRF2 in the active form, but to date, no structure has been solved.