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A) The apo BTB domain of KEAP1 showing Cys151 in green. B) The BTB domain of KEAP1 bound to the A ring of bardoxolone. This structure has been used to argue for dissociation of KEAP1 from the CUL3 complex upon activation by electrophiles. (PDB ID 4CXI). C) The KEAP1 BTB domain bound to CUL 3 with Cys150 highlighted in green. (PDB ID 4CXT). (PDB ID 5NLB).
