Table 3. Comparison of samples from patients with PDR and patients with MH – median (minimum-maximum); Mann–Whitney test.
| Cytokine | vitreous |
serum |
||||
|---|---|---|---|---|---|---|
| PDR (n=33) | MH (n=20) | P value | PDR (n=33) | MH (n=20) | P value | |
| MCP-1 (pg/ml) |
1614.98 (403.05–3990.74) |
374.17 (295.01–881.87) |
0.0001 |
72.6 (25.06–169.65) |
43.4 (30.24–76.64) |
0.02 |
| IL-8 (pg/ml) |
93.29 (20.04–295.71) |
14.49 (13.12–16.64) |
0.0001 |
11.99 (10.12–31.69) |
12.71 (11.21–13.33) |
0.84 |
| IL-6 (pg/ml) |
60.82 (13.64–798.23) |
6 (5.28–8.1) |
0.0001 |
5.46 (2.41–24.76) |
9.14 (5.81–298.4) |
0.02 |
| VEGF (pg/ml) |
304.64 (26.41–1439.3) |
4.58 (3.5–31.79) |
0.0001 |
38.66 (6.17–105.56) |
25.73 (17.62–63.61) |
0.55 |
| IL-1β (pg/ml) |
9.15 (7.51–67.36) |
10.5 (7.7–35.99) |
0.51 |
7.6 (6.91–15.16) |
7.7 (7.11–95.55) |
0.55 |
| TNF-α (pg/ml) |
13.41 (3.26–69.09) |
21.5 (5.16–38.4) |
0.25 |
5.7 (2.9–23.35) |
4.79 (4,0–98.76) |
0.82 |
| MIP-1α (pg/ml) |
9.55 (6.9–68.26) |
14.25 (9.76–47.34) |
0.004 |
15.07 (7.78–91.74) |
20.38 (11.83–91.07) |
0.27 |
| MIP-1β (pg/ml) |
12.09 (2.9–38.02) |
13.44 (0.9–14.4) |
0.31 |
18.76 (6.89–48.83) |
17.72 (15.51–60.5) |
0.80 |
| IL-10 (pg/ml) |
5.67 (4.9–8.12) |
6.05 (5.84–6.08) |
0.02 |
7.4 (5.3–15.28) |
6.63 (5.7–58.43) |
0.67 |
| IL-12 (pg/ml) | 3.17 (0.68–22.26) | 3.99 (2.56–11.18) | 0.04 | 17.7 (2.49–42.91) | 18.84 (7.09–71.71) | 0.25 |
Legend: PDR – proliferative diabetic retinopathy; MH – macular hole; IL-1β - interleukin-1β; TNF-α - tumor necrosis factor-α; MIP-1α - macrophage inflammatory protein-1α; MIP-1β - macrophage inflammatory protein-1β; MCP-1 - monocyte chemoattractant protein-1; IL-6 - interleukin-6; IL-8 - interleukin-8; IL-10 - interleukin-10; IL-12 - interleukin-12; VEGF - vascular endothelial growth factor