Table 4. Paired comparison of vitreous and serum samples from patients with PDR – median (minimum-maximum); Wilcoxon signed rank test.
| Cytokine | patients with PDR (n=33) |
||
|---|---|---|---|
| vitreous | serum | P value | |
| MCP-1 (pg/ml) |
1614.98 (403.05–3990.74) |
72.6 (25.06–169.65) |
0.0001 |
| IL-8 (pg/ml) |
93.29 (20.04–295.71) |
11.99 (10.12–31.69) |
0.0001 |
| IL-6 (pg/ml) |
60.82 (13.64–798.23) |
5.46 (2.41–24.76) |
0.0001 |
| VEGF (pg/ml) |
304.64 (26.41–1439.3) |
38.66 (6.17–105.56) |
0.0001 |
| IL-1β (pg/ml) |
9.15 (7.51–67.36) |
7.6 (6.91–15.16) |
0.002 |
| TNF-α (pg/ml) |
13.41 (3.26–69.09) |
5.7 (2.9–23.35) |
0.005 |
| MIP-1α (pg/ml) |
9.55 (6.9–68.26) |
15.07 (7.78–91.74) |
0.002 |
| MIP-1β (pg/ml) |
12.09 (2.9–38.02) |
18.76 (6.89–48.83) |
0.009 |
| IL-10 (pg/ml) |
5.67 (4.9–8.12) |
7.4 (5.3–15.28) |
0.001 |
| IL-12 (pg/ml) | 3.17 (0.68–22.26) | 17.7 (2.49–42.91) | 0.0001 |
Legend: PDR – proliferative diabetic retinopathy; IL-1β - interleukin-1β; TNF-α - tumor necrosis factor-α; MIP-1α - macrophage inflammatory protein-1α; MIP-1β - macrophage inflammatory protein-1β; MCP-1 - monocyte chemoattractant protein-1; IL-6 - interleukin-6; IL-8 - interleukin-8; IL-10 - interleukin-10; IL-12 - interleukin-12; VEGF - vascular endothelial growth factor