Table 5. Comparison of vitreous samples from patients with active PDR and inactive PDR – median (minimum-maximum); Mann–Whitney test.
| Patients with PDR (n=33) |
|||
|---|---|---|---|
| Cytokine | active PDR (n=25) | inactive PDR (n=8) | P value |
| MCP-1 (pg/ml) |
1625.84 (441.3–3990.74) |
929.35 (403.05–1625.84) |
0.003 |
| IL-8 (pg/ml) |
114.15 (37.57–295.71) |
52.53 (20.04–147.13) |
0.02 |
| IL-6 (pg/ml) |
65.08 (23.7–798.23)-295.71) |
27.43 (13.64–220.31) |
0.09 |
| VEGF (pg/ml) |
500.89 (26.41–1439.3) |
147.97 (29.86–304.64) |
0.009 |
| IL-1β (pg/ml) |
8.13 (7.51–67.36) |
19.51 (7.71–33.93) |
0.55 |
| TNF-α (pg/ml) |
13.41 (3.26–69.09) |
13.62 (3.51–31.52) |
0.91 |
| MIP-1α (pg/ml) |
6.9 (6.9–68.26) |
11.31 (6.9–28.16) |
0.49 |
| MIP-1β (pg/ml) |
12.02 (2.9–30.67) |
14.46 (4.56–38.02) |
0.52 |
| IL-10 (pg/ml) |
5.61 (4.9–6.9) |
5.78 (5.37–8.12) |
0.20 |
| IL-12 (pg/ml) | 2.77 (0.68–14.99) | 3.48 (1.07–22.26) | 0.55 |
Legend: PDR – proliferative diabetic retinopathy; MH – macular hole; IL-1β - interleukin-1β; TNF-α - tumor necrosis factor-α; MIP-1α - macrophage inflammatory protein-1α; MIP-1β - macrophage inflammatory protein-1β; MCP-1 - monocyte chemoattractant protein-1; IL-6 - interleukin-6; IL-8 - interleukin-8; IL-10 - interleukin-10; IL-12 - interleukin-12; VEGF - vascular endothelial growth factor