Table 4.
Comparisons of Unyvero vs conventional microbiological methods for all episodes, according to Unyvero version and to previous antibiotic use
| Finding | N positive | N negative | Sensitivity | Specificity (%) | PPV (%) | NPV (%) | ||
|---|---|---|---|---|---|---|---|---|
| True | False | True | False | |||||
| Total (n = 93) | ||||||||
| Pathogen identification | 65 | 6 | 1 | 19 | 77.4 | 14.3 | 91.5 | 5 |
| Resistance mechanism | 19 | 9 | 43 | 22 | 46.3 | 82.7 | 67.9 | 66.2 |
| P55 cartridge (n = 51) | ||||||||
| Pathogen identification | 39 | 1 | 1 | 10 | 79.6 | 50 | 97.5 | 9 |
| Resistance mechanism | 12 | 7 | 21 | 11 | 52.1 | 75 | 63.2 | 65.6 |
| HPN cartridge (n = 42) | ||||||||
| Pathogen identification | 26 | 5 | 0 | 9 | 74.3 | 0 | 83.9 | 0 |
| Resistance mechanism | 7 | 2 | 22 | 11 | 38.9 | 91.7 | 77.8 | 66.7 |
| Previous antimicrobial treatment (n = 75) | ||||||||
| Pathogen identification | 54 | 6 | 1 | 14 | 79.4 | 14.2 | 90 | 6.7 |
| Resistance mechanism | 15 | 8 | 31 | 21 | 41.7 | 79.5 | 65.2 | 59.6 |
| No previous antimicrobial treatment (n = 18) | ||||||||
| Pathogen identification | 13 | 0 | 0 | 5 | 72.2 | 0 | 100 | 0 |
| Resistance mechanism | 4 | 1 | 12 | 1 | 80 | 92.3 | 80 | 92.3 |
Conventional microbiological methods were considered as the gold standard
PPV positive predictive value, NPV negative predictive value, HPN hospitalised pneumonia