Table 1.

Selected adverse events of midostaurin and management [16]

Adverse event	Proposed management
Nausea/vomiting	Administration with food Administration with antiemetic
QTc prolongation	Electrocardiogram monitoring Maintain potassium and magnesium within normal limits
Interstitial lung disease and pneumonitis Pleural effusion Pulmonary hemorrhage	Monitor closely for pulmonary symptoms Discontinue midostaurin in patients who develop symptoms of interstitial lung disease

QTc corrected QTc interval