Fig. 2.

Comparison of skin temperature changes with and without limb hypothermia via cooling and cryocompression techniques. The relative changes in skin surface temperature in the a) shin, b) calf, c) toe and d) foot plantar regions over the duration of chemotherapy indicate that cryocompression (blue) offers the best temperature drop compared to continuous-flow cooling (green). The non-cooled limb was considered as control (red) which showed a minor temperature drop as well, owing to the low room temperature. ^** indicates p < 0.0001