Table 2.
Organoids from different tissues of 2019
| Tissue | Cancer type | Source of organoid | References |
|---|---|---|---|
| Lung | Non-small cell lung cancer (NSCLC) | Human primary tumor and patient-derived xenograft (PDX) | Tsao ([39], p 11) |
| Lung cancer | Human primary tumor | Ishii ([40], p 8) | |
| Pancreas | Pancreatic cancer | Human primary tumor |
Knudsen ([41], p 11) Saif ([42], p 7) Haibe-Kains ([43], p 1) |
| Human primary tumor and normal pancreas | Tuveson ([44], p 11) | ||
| Splenic xenograft mouse | Nakamura ([45], p 5) | ||
| Pancreatic ductal adenocarcinoma (PDAC) | PDX | Kim ([46], p 9) | |
| Human primary tumor |
Hippo ([47], p 6) Welsch ([48], p 6) |
||
| Esophagus | Esophageal adenocarcinoma | Barrett's esophagus (BE) tissue of mice | Quante ([49], p 8) |
| Stomach | Gastric cancer | Malignant ascites of gastric cancer | Zhan ([50], p 11) |
| Human primary tumor | Yu ([51], p 5) | ||
| Human primary tumor and normal stomach | Zavros ([52], p 1) | ||
| Breast | Breast cancer | Human primary tumor |
Raouf ([53], p 9) Corsi ([54], p 7) Skala ([55], p 6) |
| Human primary tumor and decellularized rat | Bruno ([56], p 9) | ||
| The heterogeneity of triple-negative breast cancer (TNBC) | Human primary tumor | Park ([57], p 9) | |
| Brain | Head and Neck Cancer | Normal and tumor patient-material | Oliveira ([58], p 11) |
| Head and neck squamous cell carcinoma (HNSCC) | Human primary tumor | Clevers ([59], p 7) | |
| glioblastoma (GBM) | Patient-derived glioma stem cells (GSCs) and human embryonic stem cell (hESC) | Fine ([60], p 5) | |
| Prostate | Prostatic cancer | Human primary tumor and metastatic cell lines | Kotula ([61], p 9) |
| Mouse prostate | Sawyers ([62], p 7) | ||
| Genetically engineered mouse models (GEMMs) | Goodrich ([63], p 6) | ||
| Bladder | Bladder cancer | Urine samples of dogs | Sasaki ([64], p 9) |
| Human primary tumor and normal mouse urothelium | Clevers ([65], p 3) | ||
| Liver | Liver cancer | Human primary hepatic stellate cells (HSCs) | Jung ([66], p 10) |
| Directly reprogrammed human hepatocytes (hiHeps) | Hui ([67], p 8) | ||
| Normal human cholang iocyte | Clevers ([68], p 6) | ||
| human primary tumor | Selaru ([69], p 1) | ||
| Cholangiocarcinoma (CCA) | Liver of mouse | Saborowski ([70], p 3) | |
| Hepatocellular carcinoma (HCC) | Human primary tumor | Ma ([71], p 8) | |
| Colorectal | Colon cancer | Human primary tumor | Muñoz ([72], p 11) |
| Human primary tumor and normal colon, normal mouse small intestine and colon | Nold ([73], p 10) | ||
| Human primary tumor and normal colon | Barbáchano ([74], p 7) | ||
| Colorectal cancer | Human primary tumor |
Kurisawa ([75], p 10) Kops ([76], p 5) Wiener ([77], p 6) Yao ([78], p 4) |
|
| Mouse intestinal tumor and PDX | Oshima ([79], p 7) | ||
| Human normal colon | Kitagawa ([80], p 6) | ||
| Colon signet-ring cell carcinoma (SRCC) | Human primary tumor | Peng ([81], p 11) | |
| Traditional serrated adenomas (TSAs) | Human normal colon | Sato ([82], p 10) | |
| Metastatic colorectal cancer (mCRC) | Human primary tumor | Banerjee ([83], p 2) | |
| Lymph | Non-Hodgkin lymphoma | Human primary tumor | Pérez-Galán ([84], p 7) |
| Cervix | Cervical clear cell carcinoma (cCCC) | Human primary tumor | Hippo ([85], p 9) |
| Endometrium | Endometrial cancer | Human primary tumor | Hippo ([86], p 5) |
| Endometrial disorders | The primary tissue | Vankelecom ([87], p 8) | |
| Ovary | Ovarian cancer | Human primary tumor and normal tissue | Clevers, Hans ([88], p 5) |
| Kidney | Renal cancer | Human primary tumor | Bonci ([89], p 2) |