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. 2020 Jun 25;10:10310. doi: 10.1038/s41598-020-66221-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GSEA analysis in MSA-P vs. MSA-C. Positive enrichment GSEA results comparing MSA-P vs. MSA-C on top and negative enrichment below, represented as heatmaps where green indicates MSA-P cases and orange indicates MSA-C cases, red shading represents up-regulation and blue shading down-regulation. Grey scale heatmap to the left of color heatmap indicates each gene’s corresponding biological processes. Only genes that were related to these specific biological processes have been selected with a cut-off p-value < 0.01. MSA = Multiple system atrophy (P = Parkinsonian phenotype, C = Cerebellar phenotype).