. 2020 Jun 25;3:329. doi: 10.1038/s42003-020-1051-9

Table 1.

Top SNPs associated with GIPs.

GIP^a	Lead SNP	Chr:position^b	RefA/EffA^c	Nearest gene^d	Discovery cohort (N = 265,000)					Meta-analysis of 3 replication cohorts^f
GIP^a	Lead SNP	Chr:position^b	RefA/EffA^c	Nearest gene^d	β	SE	P	P^e_(GC)	EAF (%)	β	SE	P	EAF (%)	N
GIP2	rs143384	20:34025756	C/T	GDF5	−0.020	0.003	4.87e-13	7.40e-13	59.8	−0.022	0.003	1.65e-10	58.5	191,580
GIP1	rs7628207	3:49754970	T/C	AMIGO3	−0.023	0.004	1.71e-10	2.37e-10	82.3	−0.012	0.004	4.92e-03	81.8	191,580
GIP1	rs13107325	4:103188709	T/C	SLC39A8	−0.032	0.005	8.78e-10	1.19e-09	92.6	−0.035	0.007	4.21e-08	92.6	191,580
GIP1	rs3737240	1:150483355	T/C	ECM1	0.017	0.003	2.01e-09	2.69e-09	60.4	0.010	0.003	3.17e-03	61.1	191,580
GIP1	rs73581580	9:140251458	G/A	EXD3	0.025	0.004	3.89e-09	5.15e-09	12.4	0.030	0.005	9.54e-09	12.3	174,831
GIP1	rs12705966	7:114248851	G/A	FOXP2	0.018	0.003	5.71e-09	7.52e-09	66.7	0.012	0.004	1.70e-03	67.2	191,580
GIP2	rs4985445	16:69867835	G/A	WWP2	0.017	0.003	1.56e-09	2.09e-09	54.3	0.007	0.003	0.0371	53.2	191,580
GIP2	rs548227718	5:175902724	G/A	FAF2	−0.283	0.048	3.02e-09	4.01e-09	0.1	0.096	0.060	0.1056	0.1	174,831
GIP1	rs111368900	1:53084695	G/A	GPX7	0.242	0.041	5.01e-09	6.60e-09	0.2	0.089	0.048	6.55e-02	0.2	174,831

Replicated associations are shown in bold. EAF, effect allele frequency; SE, standard error; SNP, single nucleotide polymorphism.

EAF effect allele frequency, SE standard error, SNP single nucleotide polymorphism.

^aGenetically independent phenotype with which the locus is associated.

^bChromosome: position on chromosome according to GRCh37.p13 assembly.

^cReference allele/effective allele.

^dNearest gene according to the NCBI dbSNP database (https://www.ncbi.nlm.nih.gov/snp/).

^eP-value corrected for residual inflation using the LD Score regression intercept.

^fCohorts of individuals of African, South Asian, and European ancestry from the UK Biobank (3.9%, 4.8%, and 91.3% in the total replication cohort, N = 191,580).