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. 2020 Jun 25;10:10361. doi: 10.1038/s41598-020-67301-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of UDCA on mouse bile acid homeostasis. (A) UDCA supplementation in 0.5% CA-fed mice reversed increased taurine-conjugated bile acids in the maternal serum and liver. (B) UDCA did not affect maternal hepatic mRNA expression levels of Fxr target genes. (C) UDCA supplementation in CA feeding did not affect taurine-conjugated bile acids in the fetal serum (D) UDCA supplementation in CA feeding did not affect Shp or Cyp7a1 mRNA expression levels in the fetal liver. Data are presented as mean and standard error of the mean (SEM) and were analyzed with multiple measures of ANOVA followed by Neuman Keul’s post-hoc testing. *p < 0.05 between comparisons connected by lines; NC n = 6, C A n = 6, CA + UDCA n = 4. NC, CA and CA + UDCA represent maternal diet.