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. 2020 Jun 25;10:10361. doi: 10.1038/s41598-020-67301-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of UDCA on lipid profile in mouse hypercholanemic pregnancy. (A) UDCA improved maternal serum cholesterol and LDL-cholesterol as well as hepatic cholesterol increase in gestational cholestasis. (B) UDCA reversed cholestasis induced changes in HDL and TG in the fetal serum, but it did not affect cholesterol and TG raised levels in the fetal liver. (C) UDCA reversed cholesterol and TG elevated levels associated with maternal cholestasis in placenta. Data are presented as mean and standard error of the mean (sem) and were analyzed with multiple measures of ANOVA followed by Neuman Keul’s post-hoc testing. *p < 0.05 between comparisons connected by lines. NC n = 6, CA n = 6, CA + UDCA n = 4. NC, CA and CA + UDCA represent maternal diet. FFA: free fatty acids; HDL: high-density lipoprotein; LDL: low-density lipoprotein; TG: triglyceride.