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. 2020 Jun 25;10:10361. doi: 10.1038/s41598-020-67301-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of UDCA on lipid gene expression profile in mouse hypercholanemic pregnancy. (A) Hmgcr mRNA expression in maternal liver. (B) Fas mRNA expression in maternal liver (C) Hmgcr mRNA expression in fetal liver (D) Fas mRNA expression in fetal liver. Data are presented as mean and standard error of the mean (sem) and were analyzed with multiple measures of ANOVA followed by Neuman Keul’s post-hoc testing. NC n = 6, CA n = 6, CA + UDCA n = 4. *p < 0.05 between comparisons connected by lines. NC: normal chow; CA: diet supplemented with cholic acid; CA + UDCA: diet supplemented with cholic acid + ursodeoxycholic acid; Hmcr: HMG-coA reductase; Fas: fatty acid synthase.