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. 2020 Jun 25;10:10361. doi: 10.1038/s41598-020-67301-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of UDCA on liver to body weight ratio and glucose tolerance in offspring of mouse hypercholanemic pregnancy. (A) Effects of UDCA on liver to body weight ratio (B) Effects of UDCA on glucose tolerance in NC-fed and WD-fed female offspring of maternal hypercholanemia. Data are presented as mean and standard error of the mean (sem) and were analyzed with multiple measures of ANOVA followed by Neuman Keul’s post-hoc testing. ^$p < 0.05 0′ vs 15′, *p < 0.05 15′ CA WD vs 15′ NC/CA + UDCA WD, ^#p < 0.05 30′ CA WD vs 30′ NC/CA + UDCA WD, NC n = 6, CA n = 6, CA + UDCA n = 4. NC/CA/CA + UDCA represent maternal diet; NC/WD represent offspring diet. LW/BW: liver weight/body weight; NC: normal chow; WD: western diet; GTT: glucose tolerance test.