Table 2.

Canonical pathways identified in the control versus disease comparison (treated and untreated ICP). Canonical pathways were identified using GO and KEGG tools through the MissMethyl R package. n = number of genes.

	Pathway	n	p value
Kyoto Encyclopedia of Genes and Genomes (KEGG)	Pentose phosphate pathway	30	0.018765
	Arginine and proline metabolism	49	0.021207
	Inflammatory bowel disease (IBD)	63	0.03475
	Biosynthesis of amino acids	73	0.037643
	Carbon metabolism	116	0.063953
	Th17 cell differentiation	105	0.081436
	Jak-STAT signaling pathway	152	0.089217
	Cytokine-cytokine receptor interaction	261	0.098618
	Metabolic pathways	1255	0.175827
	Cellular senescence	157	1
Gene ontology (GO)	interleukin-21 receptor activity	1	0.00058
	pyrroline-5-carboxylate reductase activity	3	0.000959
	glucose 1-dehydrogenase [NAD(P)] activity	1	0.001479
	glucose dehydrogenase activity	1	0.001479
	6-phosphogluconolactonase activity	2	0.001617
	regulation of histone H2B conserved C-terminal lysine ubiquitination	1	0.001656
	regulation of DNA double-strand break processing	2	0.001787
	L-proline biosynthetic process	5	0.001903
	proline biosynthetic process	5	0.001903
	positive regulation of skeletal muscle fiber differentiation	2	0.002738
	positive regulation of tongue muscle cell differentiation	2	0.002738
	regulation of tongue muscle cell differentiation	2	0.002738
	tongue muscle cell differentiation	2	0.002738
	glucose-6-phosphate dehydrogenase activity	2	0.002793
	histone H2B conserved C-terminal lysine ubiquitination	2	0.003224
	vagus nerve morphogenesis	2	0.003423
	regulation of histone H2B ubiquitination	5	0.003607
	proline metabolic process	9	0.00394
	regulation of skeletal muscle fiber differentiation	3	0.004158
	skeletal muscle fiber differentiation	5	0.004653