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. 2020 Jun 25;10:10378. doi: 10.1038/s41598-020-67142-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Two distinct populations of intramuscular interstitial cells of Cajal (ICC-IM) are present in the internal anal sphincter (IAS). (A) Frame of movie showing Ca²⁺ transients in two populations of GCaMP6f⁺ cells within the distal IAS (left, see also Supplemental Fig. S1). (B,C) Representative spatio-temporal (ST) maps created from cell i and iv comparing Ca²⁺ transients in Type I (B) and Type II cells (C). (D,E) Superimposed plot profiles of Ca²⁺ activity in adjacent cells highlighted in A, demonstrating the asynchrony of Type I cells (D) and the synchrony of Type II cells (E). (F) Scatter plots comparing (i) amplitude (P = 0.008), (ii) time to peak (P = 0.0057), (iii) spatial spread (P < 0.0001) and (iv) modal interval (P = 0.4413) of Ca²⁺ transients in Type I (○) and Type II ICC (○). Unpaired t test; Type I, n = 24, N = 15; Type II, n = 30, N = 18.