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. 2020 Jun 25;10:10378. doi: 10.1038/s41598-020-67142-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ca²⁺ transients in Type I intramuscular interstitial cells of Cajal (ICC-IM) are not dependent on Ca²⁺ influx via Cav_L, but rhythmic, global Ca²⁺ transients in Type II ICC-IM are. (A) Spatio-temporal (ST) map of a Type I ICC-IM under control conditions. (B) ST map of the same cell as (A) in the presence of 1 µM nifedipine. (C) Scatter plots summarising the effect of nifedipine (Nifed) on (i) amplitude (P = 0.2041), (ii) time to peak (P = 0.0146), (iii) spatial spread (P = 0.2793) and (iv) modal interval (P = 0.9999), in Type I cells (paired t test; n = 9, N = 4). (D,E) Representative ST maps of the same cell before (D) and after (E) application of 1 µM nifedipine. (F) Scatter plots summarising the effect of nifedipine on (i) amplitude (P = 0.1166), (ii) time to peak (P = 0.0912), (iii) spatial spread (P = 0.0001) and (iv) modal interval (P = 0.0013) in Type II cells. Control= ○, nifedipine = ○ (paired t test; n = 13, N = 6).