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. 2020 Jun 25;10:10378. doi: 10.1038/s41598-020-67142-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Type I cell Ca²⁺ transients are insensitive to changes in Em, whereas Type II cell Ca²⁺ transients are sensitive to changes in Em. (A) Spatio-temporal (ST) map of a Type I cell under control conditions. (B) ST map of the same cell as (A) in the presence of 10 µM pinacidil. (C) Scatter plots summarising the effect of pinacidil (Pinac) on (i) amplitude (P = 0.1245), (ii) time to peak (P = 0.9969), (iii) spatial spread (P = 0.83) and (iv) modal interval (P = 0.7318), in Type I cells (paired t test; n = 8, N = 3). (D) ST map of a Type II cell under control conditions. (E) ST map of the same cell as (D) in the presence of 10 µM pinacidil. Type II cell rhythmic Ca²⁺ transients are suppressed by changes in Em. (F) Scatter plots summarising the effect of pinacidil on (i) amplitude (P = 0.0138), (ii) time to peak (P = 0.85), (iii) spatial spread (P = 0.0001) and (iv) modal interval (P = 0.0353) in Type II cells. Control= ○, pinacidil = ○ (Paired t test; n = 9, N = 6).