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. 2020 Jun 25;10:10378. doi: 10.1038/s41598-020-67142-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of anoctamin 1 (ANO1) does not abolish Ca²⁺ transients in Type I cells, but it does abolish Type II rhythmic global cell Ca²⁺ transients. (A) Spatio-temporal (ST) map of Type I cell Ca²⁺ transients under control conditions. (B) ST map of Ca²⁺ activity in the same cell as (A) after the application of 10 µM CaCCinh-A01. (C) Scatter plots summarising the effect of CaCCinh-A01 (10 µM) on (i) amplitude (P = 0.46), (ii) time to peak (P = 0.7818), (iii) spatial spread (P = 0.8007) and (iv) modal interval (P = 0.103), in Type I cells (Paired t test; n = 8, N = 4). CaCCinh-A01 inhibits rhythmic Ca²⁺ transients in Type II cells. (D) ST map from a Type II cell under control conditions. (E) ST map from the same cell after the application of CaCCinh-A01 (10 µM). (F) Scatter plots summarising the effect of CaCCinh-A01 on (i) amplitude (P = 0.2191), (ii) time to peak (P = 0.7768), (iii) spatial spread (P = 0.0001) and (iv) modal interval (P = 0.0639) in Type II cells. Control= ○, CaCCinh-A01 = ○. (paired t test; n = 8, N = 6).