Table 1.
Baseline characteristics of the patients
| Characteristics | No. of patients (%) | |
|---|---|---|
| Cystine/theanine (n = 52) | Placebo (n = 48) | |
| Age, years | ||
| Median (range) | 63.5 (36–79) | 65.5 (46–80) |
| 20 ≤ age < 71 | 38 (73.1) | 35 (72.9) |
| 71 ≤ age ≤ 80 | 14 (26.9) | 13 (27.1) |
| Sex | ||
| Male | 31 (59.6) | 25 (52.1) |
| Female | 21 (40.4) | 23 (47.9) |
| Height, median (range) | 163 (144.2–179.0) | 160.1 (144.0–181.1) |
| Body weight, median (range) | 60.1 (37.0–123.5) | 56.4 (37.2–95.3) |
| ECOG performance status | ||
| 0 | 52 (100) | 47 (97.9) |
| 1 | 0 (0.0) | 1 (2.1) |
| Tumor location | ||
| Colon | 39 (75.0) | 35 (72.9) |
| Rectum | 13 (25.0) | 13 (27.1) |
| Histology* | ||
| Papillary adenocarcinoma | 1 (1.9) | 0 (0.0) |
| Tubular adenocarcinoma | ||
| Well-differentiated type | 10 (19.2) | 6 (12.5) |
| Moderately differentiated type | 34 (65.4) | 37 (77.1) |
| Poorly differentiated adenocarcinoma | ||
| Solid type | 1 (1.9) | 0 (0.0) |
| Nonsolid type | 2 (3.8) | 0 (0.0) |
| Mucinous adenocarcinoma | 0 (0.0) | 0 (0.0) |
| Signet ring cell carcinoma | 0 (0.0) | 0 (0.0) |
| Medullary carcinoma | 0 (0.0) | 0 (0.0) |
| Adenosquamous carcinoma | 0 (0.0) | 0 (0.0) |
| Squamous cell carcinoma | 0 (0.0) | 0 (0.0) |
| Other carcinoma | 0 (0.0) | 3 (6.3) |
| Clinical stage | ||
| II | 17 (32.7) | 11 (22.9) |
| IIIa | 30 (57.7) | 30 (62.5) |
| IIIb | 2 (3.8) | 5 (10.4) |
| Institutions | ||
| Sendai Open Hospital | 26 (50) | 23 (47.9) |
| Iwate Prefectural Central Hospital | 6 (11.5) | 7 (14.6) |
| Yamagata Prefectural Central Hospital | 8 (15.4) | 8 (16.7) |
| Tohoku Rosai Hospital | 0 (0.0) | 2 (4.2) |
| Miyagi Cancer Center | 1 (1.9) | 0 (0.0) |
| Sendai Medical Center | 9 (17.3) | 8 (16.7) |
| Ishinomaki Red Cross Hospital | 2 (3.8) | 0 (0.0) |
ECOG Eastern Cooperative Oncology Group
*Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma, Ninth Edition (Japanese Society for Cancer of the Colon and Rectum)