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. 2020 Jun 26;10:16. doi: 10.1186/s12348-020-00207-1

Table 1.

A brief review of some of the recent reports of CMV retinitis in immunocompetent patients. (Abbreviations: Diabetes mellitus (DM), injection of triamcinolone acetonide (IVTA), central retinal vein occlusion (CRVO))

case (Reference) Age Laterality Systemic and ocular history Manifestation Treatment Initial visual acuity Final visual acuity
1 [1] 61 Right eye None Fine keratic precipitates, 1+ aqueous cells, mild vitritis, patches of hemorrhagic retinitis and perivascular sheathing Intravitreal ganciclovir followed by oral valganciclovir 4/20 8/20
2 [9] 51 Both eyes None Fine keratic precipitates, 1+ aqueous cell, and flare, 1+ vitritis in both eyes, areas of confluent retinitis and hemorrhage and peripheral necrosis and fibrosis Oral valganciclovir

20/60 (right eye) and 20/50

(left eye)

20/70 (right eye)

and 20/60 (left eye)

3 [5] 75 Left eye Diabetes mellitus (DM), intravitreal injection of triamcinolone acetonide (IVTA) The rare cell in the anterior chamber, no vitreous cells, arcuate retinal whitening (which appeared full-thickness) along the temporal vascular arcades Intravitreal ganciclovir followed by oral valganciclovir 20/80 20/400
4 [2] 77 Right eye DM, IVTA Fine keratic precipitates, 2 + vitritis, foci of oedematous retinitis with dense retinal whitening, hemorrhages and inflammatory retinal vascular sheathing

Intravitreal injection of ganciclovir + intravenous administration

of ganciclovir followed by oral valganciclovir

counting fingers at 1.8 m 20/200
5 [2] 69 Right eye DM, central retinal vein occlusion (CRVO), Vitrectomy surgery, IVTA Keratic precipitates, 2 + cells in the anterior chamber, moderate vitritis, necrotizing retinitis extending throughout the entire retina with hemorrhages, retinal opacification and periphlebitis

Intravitreal injection of ganciclovir + intravenous administration

of ganciclovir followed by oral valganciclovir

20/200 20/400
6 [3] 54 Left eye Carrier of human T-cell lymphotropic virus type 1, DM, CRVO, vitrectomy surgery, IVTA Small granulomatous keratic precipitates, 1+ aqueous cell and flare, 1+ vitritis, papillitis, retinal vasculitis, and retinal exudates

Intravenous injections of ganciclovir + Intravitreous

injections of foscarnet

1.0 0.5
7 [10] 78 Right eye IVTA Keratic precipitates, 2+ cells in the anterior chamber and moderate vitritis, hemorrhagic sheathing of branch arteries, inflammatory vascular sheathings in the periphery and areas of retinal whitening in the peripheral superior nasal part Intravitreous injections of ganciclovir + intravenous ganciclovir followed by oral valganciclovir 20/40 20/25
8 [4] 61 Left eye DM, intravitreal injection of bevacizumab 4+ cells and in the anterior chamber, dense vitritis and retinal vascular obliteration, necrotizing retinitis with dense retinal whitening and hemorrhage Intravenous administration of ganciclovir Hand motions Not reported
9 [6] 75 Left eye DM, intravitreal injection of ranibizumab Mild anterior segment inflammation, low-grade vitritis, and foci of retinitis in the peripheral fundus along with retinal and subretinal hemorrhages, exudates, and macular edema Intravitreal ganciclovir 4/10 5/10
10 [11] 74 Right eye Multiple intraocular surgeries, long-term use of immunosuppressive eye drops such as corticosteroids and cyclosporine No inflammatory cells in the anterior chamber or the anterior vitreous, confluent exudate the entire peripheral retina Intravenous ganciclovir+ intravitreal ganciclovir injections followed by oral valganciclovir Hand motions Not reported