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. 2020 Jun 19;11:916. doi: 10.3389/fphar.2020.00916

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Copyright © 2020 Lesage, Gibson, Marceau, Ambrosi, Saupe, Katzer, Loenders, Charest-Morin and Knolle

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schild plot analysis of Figure 3 data where a point in the regression represents one day of experimental data for a given antagonist concentration. The identity of the tested antagonist is icatibant (A), Compound 1 (B), Compound 2 (C) and Compound 3 (D). Two-way ANOVA indicated that the antagonist drug identity and concentration determined the variation of log(DR-1) values (P < 10^-4 for each). Values different from those of icatibant: *P < 0.05; **P < 0.01; values different from those of Compound 1: ^‡P < 0.05 (Bonferroni post-hoc test).