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Affinities, IC50 and Ki values at the human B2 receptor derived from the [3H]BK binding competition assay.
| IC50 (nM) | Ki (nM) | n | |||||
|---|---|---|---|---|---|---|---|
| Mean | S.D. | Geometric mean | Mean | S.D. | Geometric mean | ||
| Icatibant | 1.21 | 0.46 | 1.15 | 0.64 | 0.26 | 0.60 | 6 |
| Compound 1 | 7.4 | – | 7.4 | 3.8 | – | 3.8 | 1 |
| Compound 2 | 7.6 | – | 7.6 | 3.9 | – | 3.9 | 1 |
| Compound 3 | 0.97 | 0.03 | 0.97 | 0.50 | 0.02 | 0.50 | 3 |
