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Antagonist potencies, IC50 and Kb values at the human B2 receptor in the calcium mobilization assay.
| IC50 (nM) | Kb (nM) | n | |||||
|---|---|---|---|---|---|---|---|
| Mean | S.D. | Geometric mean | Mean | S.D. | Geometric mean | ||
| Icatibant | 27.8 | 7.6 | 25 | 3.19 | 1.47 | 2.81 | 13 |
| Compound 1 | 11.3 | 4.1 | 11 | 1.30 | 0.46 | 1.24 | 3 |
| Compound 2 | 9.57 | 6.46 | 8.3 | 1.08* | 0.71 | 0.95 | 3 |
| Compound 3 | 2.13 | 0.12 | 2.13 | 0.24** | 0.02 | 0.24 | 3 |
ANOVA, P < 0.01. *P < 0.05; **P < 0.01 for comparison with the common control value, icatibant Kb (Dunnett's test).
