Table 5.
Agonist EC50 values in specificity experiments (Figure 5).
| Antagonist | Agonist | Antagonist concentration | Agonist EC50 (nM) | 95% confidence limits on EC50 values |
|---|---|---|---|---|
| Compound 2 | Serotonin | 0 | 7.5 | 5.9 – 9.5 |
| 10 μM | 4.0 | 2.6 – 6.1 | ||
| U-46619 | 0 | 24.9 | 17.2 – 36.2 | |
| 10 μM | 24.5 | 18.3 – 32.9 | ||
| Compound 3 | Serotonin | 0 | 17.2 | 11.5 – 25.8 |
| 1 μM | 20.5 | 14.5 – 28.9 | ||
| U-46619 | 0 | 14.1 | 9.7 – 20.5 | |
| 1 μM | 11.3 | 8.8 – 15.5 | ||
| Sar-[D-Phe8]des-Arg9-BK | 0 | 92.0 | 62.9 – 134.7 | |
| 1 μM | 72.3 | 43.9 – 119.2 | ||
| icatibant | Sar-[D-Phe8]des-Arg9-BK | 0 | 112.1 | 92.2 – 139.3 |
| 1 μM | 68.2 | 42.5 – 109.4 |